Born to actor parents, he began his career in 1989 in the Mexican series Teresa
First costarred with close friend Diego Luna in the 1992 teen series El Abuelo y Yo
In 2000, he burst onto the international scene in Alejandro González Iñárritu's Amores Perros
He appeared in Iñárritu's Oscar-nominated drama Babel in 2006
Along with Luna, he received the Marcello Mastroianni Award at the Venice Film Festival for their performances in 2002's Y Tu Mamá También
Twice played revolutionary Ernesto "Che" Gueveara, first in the 2002 TV-movie Fidel and again in the 2004 film Diarios de Motocicleta (The Motorcycle Diaries)
In 2005, he, Luna and Pablo Cruz formed the production company Canana Films
Collaborated with singer Devendra Banhart on the duet "Cristobal," featured on Banhart's 2007 album, Smokey Rolls Down Thunder Canyon
Supports Amnesty International and co-directed the short-film collection The Invisibles for the organization to shed light on the plight of Mexican migrants
Awards
2017Golden Globe-Best Performance by an Actor in a Television Series - Musical or Comedy:nominated
2016Golden Globe-Best Performance by an Actor in a Television Series - Musical or Comedy:winner
2008Vancouver Film Critics-Best Performance by a Supporting Actor in a Canadian Film:nominated