- Started acting on stage at an early age, as her father was the founder and executive director of Raleigh's Theatre in the Park.
- Relocated to Hollywood with her mother after her parents' divorce.
- Auditioned for the role of Claudia in Interview with the Vampire, but lost to Kirsten Dunst.
- Earned her GED at 15.
- Has a black belt in Tae Kwon Do.
- Once played Helen Keller to her mother's Annie Sullivan under the direction of her father in a stage production of The Miracle Worker.
- 2004, Golden Globe — Best Performance by an Actress in a Motion Picture - Drama: Nominee
- 2003, Screen Actors Guild Awards — Outstanding Performance by a Female Actor in a Leading Role: Nominee
- 2011, Emmy — Outstanding Supporting Actress in a Miniseries or a Movie: Nominee
- 2012, Golden Globe — Best Performance by an Actress in a Supporting Role in a Series, Miniseries or Motion Picture Made for Television: Nominee
- 2016, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Drama Series: Nominee
- 2017, Emmy — Outstanding Lead Actress in a Drama Series: Nominee
- 2018, Emmy — Outstanding Lead Actress in a Drama Series: Nominee
- 2017, Golden Globe — Best Performance by an Actress in a Television Series - Drama: Nominee
- 2016, Critics' Choice Awards — Best Actress in a Drama Series: Winner
- 2004, Critics' Choice Awards — Best Young Actor/Actress: Nominee
- Marilyn Manson — Ex-fiancé
- Jamie Bell — Husband (separated)
- Zach Villa — Fiancé
- Dana Wood — Brother
- Ira David Wood III — Father
- Ira David Wood — Brother
- Carol Winstead Wood — Aunt
- Sara Lynn Moore — Mother
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