Launched acting career as an intern at the Chelsea Theatre Center in New York City
Starred as Larry Fine in the 2000 TV-movie The Three Stooges
Wrote the solo show Time on Fire and the book Time on Fire: My Comedy of Terrors, both autobiographical works about his battle with leukemia
Has contributed articles to numerous magazines, including The New Yorker, Elle, Mirabella and O, the Oprah Magazine
Released a collection of autobiographical essays, It's Only Temporary: The Good News and the Bad News of Being Alive, in 2008
Portrayed divorce lawyer Harry Goldenblatt in the HBO series Sex and the City for three seasons, then reprised the role for the 2008 movie and its 2010 sequel