- One of Mexico's most popular actors.
- Is the Spanish-language voice of Donkey in Shrek and Shrek 2.
- Has a degree in Film Directing from the Mexican Institute of Cinematography and Theatre, and one in Acting from Televisa's Acting School.
- Hosted the 2009 and 2010 Latin Grammy Awards.
- Landed the role of a Mexican gardener in the 2011 Adam Sandler comedy Jack and Jill after Sandler's staff suggested Derbez for the part.
- Has authored two books on comedy.
- Aislinn Derbez — Daughter
- Alessandra Rosaldo — Wife
- Sylvia Derbez — Mother
- Vadhir Derbez — Son
- Victoria Ruffo — Ex-wife
- Eugenio Gonzales Salas — Father
- Jose Eduardo Derbez — Son
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