- Studied acting with William Esper.
- Joined the Boston Repertory Theater in 1971.
- Directed two episodes of St. Elsewhere.
- Moved with his family to Philadelphia—his wife Susan Wheeler Duff's hometown—after their Los Angeles home was destroyed in the 1994 earthquake.
- Worked as a Boston taxi driver to make ends meet in 1972; 30 years later, he landed a role as a Philly cabbie in the drama series Hack.
- Was the first English-speaking actor nominated for the Golden Horse Award (Taiwan's Chinese-language Oscar) for his supporting performance in the 2002 film Double Vision.
- Appeared in the 2007 Broadway play The Seafarer, in which he was the only American in an all-Irish cast.
- Has a number of allergies, which have hampered his ability to go out to restaurants and clubs while on location.
- 2007, Emmy — Outstanding Guest Actor in a Drama Series: Nominee
- 2013, Canadian Screen Awards — Performance by an Actor in a Leading Role: Nominee
- 1996, Independent Spirit Awards — Best Supporting Male: Nominee
- 2008, Emmy — Outstanding Supporting Actor in a Miniseries or a Movie: Nominee
- 1999, Screen Actors Guild Awards — Outstanding Performance by a Cast in a Motion Picture: Nominee
- Charles Morse — Father
- Jacquelyn Morse — Mother
- Susan Wheeler Duff — Wife