Set out to be a concert pianist, originally studying music at Yale before making the switch to acting
Worked as a security guard and sold ties at Bloomingdale's while trying to make it in New York as an actor
Was stage legend Uta Hagen's last leading man
They costarred in a 2001 Los Angeles production of the two-character comedy Six Dance Lessons in Six Weeks; Hagen insisted on waiting for Pierce to finish his season of Frasier so that they could appear together on Broadway, but while waiting she had a stroke (and later died)
In 2005, made his Broadway musical debut in Monty Python's Spamalot
Is a national board member of the Alzheimer's Association; lost his father and grandfather to the disease
Awards
2004Emmy-Outstanding Supporting Actor in a Comedy Series:winner
2003Screen Actors Guild Awards-Outstanding Performance by an Ensemble in a Comedy Series:nominated
2002Screen Actors Guild Awards-Outstanding Performance by an Ensemble in a Comedy Series:nominated
2002Emmy-Outstanding Supporting Actor in a Comedy Series:nominated
2001Screen Actors Guild Awards-Outstanding Performance by an Ensemble in a Comedy Series:nominated
2001Emmy-Outstanding Supporting Actor in a Comedy Series:nominated
2001Golden Globe-Best Performance by an Actor in a Supporting Role in a Series, Miniseries or Motion Picture Made for Television:nominated
2000Emmy-Outstanding Supporting Actor in a Comedy Series:nominated
2000Screen Actors Guild Awards-Outstanding Performance by an Ensemble in a Comedy Series:nominated
1999Screen Actors Guild Awards-Outstanding Performance by a Male Actor in a Comedy Series:nominated
1999Screen Actors Guild Awards-Outstanding Performance by an Ensemble in a Comedy Series:winner
1999Emmy-Outstanding Supporting Actor in a Comedy Series:winner
1998Screen Actors Guild Awards-Outstanding Performance by an Ensemble in a Comedy Series:nominated
1998Screen Actors Guild Awards-Outstanding Performance by a Male Actor in a Comedy Series:nominated
1998Golden Globe-Best Performance by an Actor in a Supporting Role in a Series, Miniseries or Motion Picture Made for Television:nominated
1998Emmy-Outstanding Supporting Actor in a Comedy Series:winner
1997Golden Globe-Best Performance by an Actor in a Supporting Role in a Series, Miniseries or Motion Picture Made for Television:nominated
1997Emmy-Outstanding Supporting Actor in a Comedy Series:nominated
1997Screen Actors Guild Awards-Outstanding Performance by an Ensemble in a Comedy Series:nominated
1996Emmy-Outstanding Supporting Actor for a Comedy Series:nominated
1996Golden Globe-Best Performance by an Actor in a Supporting Role in a Series, Miniseries or Motion Picture Made for Television:nominated
1996Screen Actors Guild Awards-Outstanding Performance by a Male Actor in a Comedy Series:nominated
1996Screen Actors Guild Awards-Outstanding Performance by an Ensemble in a Comedy Series:nominated
1995Screen Actors Guild Awards-Outstanding Performance by a Cast in a Motion Picture:nominated
1995Golden Globe-Best Performance by an Actor in a Supporting Role in a Series, Miniseries or Motion Picture Made for Television:nominated
1995Emmy-Outstanding Supporting Actor in a Comedy Series:winner
1995Screen Actors Guild Awards-Outstanding Performance by a Male Actor in a Comedy Series:winner
1995Screen Actors Guild Awards-Outstanding Performance by an Ensemble in a Comedy Series:nominated
1994Emmy-Outstanding Supporting Actor in a Comedy Series:nominated
1994Screen Actors Guild Awards-Outstanding Performance by an Ensemble in a Comedy Series:nominated