Made his television debut in The Outsiders, which was executive produced by Francis Ford Coppola
Met Courteney Cox in 1996 on the set of Scream; in 2004, they formed Coquette Productions
Starred in the 2000 wrestling comedy Ready to Rumble and shortly thereafter won World Championship Wrestling's title of World Heavyweight Champion
In 2006, he was awarded the American Film Institute's Platinum Circle Award, along with other members of the Arquette clan, for the family's contributions to the entertainment industry
Chairman of the Entertainment Council for Feeding America, an organization that supplies food to low-income Americans
Executive producer of TV shows Dirt and Cougar Town, both starring then-wife Cox