- Is of Jewish and Italian heritage.
- Worked as an intern at the Village Voice.
- Has performed at such events as the Montreal Just For Laughs Festival, the HBO Aspen Comedy Festival and the Las Vegas Comedy Festival.
- Performs with the all-female comedy troupe Variety Shac.
- Starred in the web series Making Friends and All My Exes.
- In 2012, began hosting the weekly podcast Call Chelsea Peretti.
- 2014, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Comedy Series: Nominee
- Jonah Peretti — Brother
- Jordan Peele — Husband
- Barnard College, New York, New York, United States (2000)