- Studied ballet as a child.
- Organized a front-yard theater group at age 12 in Macon, GA.
- Met her husband, Michael Emerson, while the two were appearing in Hamlet at the Alabama Shakespeare Festival.
- Appeared as the mother of Emerson's Lost character Ben Linus in a flashback sequence.
- Has played Felicity Huffman's sister twice: first in the 2005 film Transamerica, and later in a 2007 episode of Desperate Housewives.
- Cofounded the production company Daisy 3 Pictures in 2004.
- 2014, Critics' Choice Television Awards — Best Guest Performer in a Drama Series: Nominee
- 2016, Emmy — Outstanding Guest Actress in a Drama Series: Nominee
- 2009, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Drama Series: Nominee
- 2013, Emmy — Outstanding Guest Actress in a Drama Series: Winner
- John G. Preston — Brother
- Michael Emerson — Husband
- Pam Preston — Mother
- Leslie — Sister
- Ray Preston — Father
- University of Evansville, Evansville, Indiana, United States (BFA, 1990); The Juilliard School, New York, New York, United States (1994)