- A former girlfriend of Jerry Seinfeld, she's rumored to be one of the inspirations for the Elaine character on Seinfeld.
- Was discovered by David Letterman—who caught her act in a comedy club—and has performed on his late-night show many times.
- Is a vegan.
- Author of the essay collection When You Lie About Your Age, The Terrorists Win (2009).
- Bought the handwritten note believed to be used by Michael Vick during his public apology after he pleaded guilty to dogfighting.
- Was the first contestant to be fired in the 2010 installment of Celebrity Apprentice.
- 1996, Emmy — Outstanding Comedy Series: Nominee
- 2016, Writers Guild Awards — Comedy/Variety - Music, Awards, Tributes - Specials: Nominee
- 2012, Emmy — Outstanding Writing for a Variety Special: Nominee
- 1997, Emmy — Outstanding Comedy Series: Nominee
- 2019, Writers Guild Awards — Comedy/Variety - Music, Awards, Tributes - Specials: Nominee
- 2010, Emmy — Outstanding Writing for a Variety, Music or Comedy Special: Nominee
- Ritch Shydner — Ex-husband
- Bruno Leifer-Wolf — Son
- Jerry Seinfeld — Ex-significant Other
- Jane — Sister
- Anna Leifer — Mother
- Seymour Leifer — Father
- Marvin — Brother
- Paul Reiser — Ex-significant Other
- Lori Wolf — Wife
- Attended State University of New York, Binghamton, New York, United States; attended City University of New York, Queens College, Queens, New York, United States
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