Began her modeling career at 11 months old, when she appeared in an Ivory soap ad photographed by Francesco Scavullo.
First major film role was in Louis Malle's 1978 drama Pretty Baby, in which she played a child growing up in a brothel.
At 14, was the youngest model to appear on the cover of Vogue.
At 15, starred in a controversial Calvin Klein jeans commercial in which she said, "You want to know what comes between me and my Calvins? Nothing."
Put her career on hold from 1983 to '87 to attend Princeton University.
A popular guest spot on Friends led to NBC creating the sitcom Suddenly Susan for her in 1996.
Starred in several Broadway revivals throughout the 2000s, including Grease, Cabaret and Chicago.
Was famously criticized by Tom Cruise over taking medication for postpartum depression; he later apologized, and she attended his 2006 wedding to Katie Holmes.
Appeared in the recurring role of Miley's late mom on the Disney Channel's Hannah Montana.
Is the author of several books, including the memoirs The Brooke Book (1983) and Down Came the Rain: My Journey Through Postpartum Depression (2005) and the children's book It's the Best Day Ever, Dad! (2009).
In 2011, took over the part of Morticia Addams in the Broadway musical version of The Addams Family.