- Started his career as a salesman on the Atlantic City boardwalk; one of the first products he pitched was WashMatik, a car-wash aid.
- Hired by Orange Glo International in 1996 to promote its line of cleaners, including OxiClean, Orange Glo and Kaboom, on the Home Shopping Network.
- Starred in the documentary series Pitchmen on the Discovery Channel, alongside Anthony "Sully" Sullivan.
- Appeared on The Tonight Show With Conan O'Brien on June 23, 2009, only five days before his death.
- Deborah Mays — Wife
- Billy Mays III — Son
- Joyce Mays — Mother
- Dolores 'Dee Dee' Mays — Ex-wife
- Elizabeth Mays — Daughter
- Attended West Virginia University, Morgantown, West Virginia, United States