- Was inspired to be an actor after watching her uncle perform on stage in Germany.
- First acted at age five playing the role of the angel Gabriel in a school play.
- Got her first professional role at age 15 playing a bully on the TV series Grange Hill.
- Was invited to join the Royal Shakespeare Company after finishing the two-year program at the Royal Academy of Dramatic Arts in London.
- Made film debut in 1989's The Cook, the Thief, His Wife & Her Lover.
- Earned critical acclaim in 1996 for her portrayal of the title role in The Fortunes and Misfortunes of Moll Flanders.
- Was noticed by producers of ER for her performance in Moll Flanders and took the role of Dr. Elizabeth Corday on the series in 1997.
- Underwent a very public divorce from actor Ralph Fiennes in 1997 (whom she met while attending London's Royal Academy of Dramatic Art) after he left her for actress Francesca Annis.
- Complained of ageism in Hollywood at age 41 after her contract was not renewed on ER because, according to Kingston, producers wanted to concentrate on the younger cast's story lines.
- Played Nurse Ratched in the London revival of One Flew Over the Cuckoo's Nest in 2006.
- 1998, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Drama Series: Winner
- 1997, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Drama Series: Winner
- 2000, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Drama Series: Nominee
- 1999, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Drama Series: Nominee
- Susie Kingston — Sister
- Salome Violetta Haertel — Daughter
- Walter Renneisen — Uncle
- Florian Haertel — Husband
- Ralph Fiennes — Ex-husband
- The Royal Academy of Dramatic Art, London, England
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