- As a teen, served some time in jail for stealing cars.
- A longtime fan of All My Children, he dedicated songs to the character Erica Kane and even appeared on the soap in 1995.
- In 2000, he was the first major recording artist to have an album (Devotion) released in the audio DVD format.
- Is a devout Catholic and was honored with the James Cardinal Gibbons Medal in 2002.
- Lost his New Orleans home during Hurricane Katrina.
- Met his second wife, photographer Sarah A. Friedman, during a People magazine photo shoot in 2008, when she was hired to do a portrait of the Neville Brothers.
- 1989, Grammy — Best Pop Performance by a Duo or Group with Vocal: Winner
- 1990, Grammy — Best Pop Performance by a Duo or Group with Vocal: Winner
- 1994, Grammy — Best Country Collaboration With Vocals: Winner
- 1989, Grammy — Best Pop Instrumental Performance: Winner
- Sarah A. Friedman — Wife
- Amelia Neville — Mother
- Jason Neville — Son
- Athelgra Neville — Sister
- Ivan Neville — Son
- Joel Neville — Wife (deceased)
- Arthur Neville — Father
- Art Neville — Brother
- Aaron Neville Jr. — Son
- Charles Neville — Brother
- Cyril Neville — Brother
- Ernestine Neville — Daughter
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