Sam and Dean investigate a case that leads them to a devout religious family who live off the grid. The brothers realize that the parents are hiding a huge secret that could destroy them all. Meanwhile, Dean struggles to accept Mary's latest decision.
Lucifer realizes that as rock star Vince Vincente he can get his fans to do whatever he wants. Thrilled with this power, Lucifer arranges to play a secret VIP concert in order to kill all of them. But Sam, Dean and Castiel enter the underbelly of the music industry to stop him.
Lucifer's search for power and influence in a vessel lands him in the White House where he the president unknowingly makes a deal with the devil. But Sam, Dean, Castiel, Crowley and Rowena band together to fight the Dark Lord.
After being arrested for the attempted assassination of the President of the United States, Sam and Dean must find a way out of an underground, government-run, detention facility in the middle of nowhere. Determined to find her sons, Mary and Castiel seek assistance from an unlikely source.
Lily Sunder steeps herself in black magic, honing her powers for over a century, to exact revenge on a band of angels who murdered her family. Meanwhile, Sam and Dean try to prevent Castiel from becoming her next victim.
Sam and Dean investigate a murder at a museum and learn a ghost from a merchant ship that sank in 1723 may be at the heart of the mystery. They also realize the ship is the same one that Crowley's son Gavin should have been aboard, so they enlist help from Rowena to track Gavin down. Meanwhile, Kelly Kline, still pregnant with Lucifer's child, takes refuge with a demon after an angel tries to kill her.
An attack by an invisible hellhound at a campsite leads Sam and Dean to investigate the mysterious circumstances. Meanwhile, two of Crowley's own personal demons uncover what he has been hiding; and Castiel gets a lead on Kelly Kline.
Sam and Dean search for a werewolf, and let Mick Davies tag along on the case. They soon run into Claire Novak, but their reunion is short lived after Claire is bitten and the brothers race to find a way to help her before she turns.
Sam and Dean investigate a missing person's case in a small town. The lead witness tells them the attacker was a man with the head of a goat. The brothers aren't sure what to believe, but when the witness goes missing they realize the town is hiding a dark secret.
Sam comes up with a way to stop Lucifer's baby, but Castiel has something else in mind for Kelly; Dean is furious when he finds out someone stole the colt; Kelly makes a bold choice about the baby's future.
Alicia Banes calls Mary for help after her mother goes missing. Sam answers Mary's phone and he and Dean head out to help Alicia and her twin brother find their mother who was hunting a powerful witch. Meanwhile, Mary starts to have some doubts about the British Men of Letters.
Sam and Dean are alarmed when they learn hunters are being killed by suspicious "accidents" all over the country. They decide it is best to find Mary and make sure she's safe. Meanwhile, Toni returns to the country and faces off with Mary.