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Gamaliel and Morris are two colorful characters, best friends since childhood, one Mexican and one gringo who engage together in people trafficking but who deep down have a good heart. After years of not seeing each other, they reunite and decide to join forces to create a transnational corporation: Run Coyote Run, a "touristic adventure" travel agency, as they like to call it, specialized in smuggling people illegally to the US.
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Episode 1
Gama and Morris go back to Naco escaping from the American police. They find the town harassed by drug dealers fighting over the plaza. Unable to locate Wendy, they decide to go back to the US, running away from El Dragon's revenge.