A spin-off from 'CSI: Crime Scene Investigation' follows a South Florida forensics team headed by the brooding Horatio Caine. Against a backdrop of simmering ethnic and cultural tensions, Caine's team probes cases similar to those of their Las Vegas counterparts.
Horatio investigates the murder of a probation officer and soon comes to believe that one of the chief suspects in the crime may be a son he never knew he had. To confirm his suspicions, he hires Yelina to investigate the boy's background. Later, a prison guard's wife is kidnapped and held for ransom.
A legendary football hero is stabbed to death while talking to a reporter on the phone. The case hits an immediate snag when the lab isn't allowed to take the body because of the victim's wish to be cryogenically frozen. Robbery appears to be the motive, but as the probe deepens it's learned the sports icon wasn't revered by everyone. Also, Stetler learns about the relationship between Calleigh and Jake, and puts pressure on them to end it.
A man is strangled to death near a hotel pool during a total eclipse of the sun and evidence found at the scene suggests the killer may not be fully human. Twelve hours later, a woman is murdered in similar fashion in her apartment. The probe reveals the first victim dealt drugs out of a hotel cabana, while the second victim spent most of her time in Internet chat rooms. Also, Ryan is reinstated, and Alexx is taken to a hospital after collapsing in the lab.
A model dies by electrocution on a runway during a fashion show, and the investigation reveals the death wasn't an accident but murder. The probe also turns up evidence that the victim is connected to the man who kidnapped Horatio's son, which may mean that Kyle is in greater danger than Horatio feared.
A wealthy family's nanny is murdered during a lavish party. The investigation reveals the victim had just been fired from her job by the children's jealous mother and that $250,000 is missing from the house safe. The dead woman knew the combination, as did the couple's other nanny.
A billionaire is murdered in his Miami home just before he can sign an important legal document. When Horatio arrives on the scene, he's shocked to discover that the victim's widow (Elizabeth Berkley) is his former lover and Kyle's mother. She also is a leading suspect in her husband's homicide. In court, Kyle goes on trial for kidnapping and his mother makes it clear she will doing anything to regain custody of him.
Part 1 of 2. Horatio investigates a murder that may be connected to Julia (Elizabeth Berkley), but she has him extradited to Brazil to face murder charges for a killing he committed two years ago. Meanwhile, Calleigh is cyberstalked by someone who is putting her alleged work mistakes on the Internet.
Conclusion. Horatio faces armed thugs in Brazil who aim to gun him down for killing his wife's murderer two years ago. Back in Miami, the team searches for Calleigh after she is kidnapped by two crooks who want her to cover up a murder they committed. The crooks also want her help in robbing players in an illegal high-stakes poker game.
Two men who prey on underage girls are murdered on the same day. The first is run down outside of his office building, and the second one is shot to death at an outdoor restaurant. Both victims had recently been exposed on a local news program as predators. The investigation reveals that a girl who is involved in an Internet chat room may be in danger.
A man is killed when his car plunges into a sinkhole. When the scene is investigated a tunnel is discovered with a woman's body in it, and the tunnel leads to a bank vault that's been robbed. Complicating matters is the fact that the thieves were targeting a specific safe-deposit box to steal a particular item.
Alexx is stunned when her son is the prime suspect in the murder of a convicted drug dealer who was just released from prison. The victim died when he was struck by a heavy piece of slate that was dropped from a bridge as he rode a personal watercraft underneath it. The news is upsetting to Alexx and the ordeal makes her reconsider whether she should continue to work or quit and be at home.
A phony 911 call leads to a man being gunned down in his home by a SWAT team. The investigation reveals the victim was involved in a lawsuit and that his wife was having an affair. Complicating matters is a sleazy private investigator (Tom Sizemore), who is hired by the case's chief suspect. He attempts to dismantle Horatio's team piece by piece to prevent his client from going to prison.
In the sixth-season finale, a man dies when he falls from a vacant high-rise building. When a new medical examiner arrives at the scene to inspect the body, she is gunned down. The investigation reveals the man was involved in illegal ammunition sales. But the case gets personal when Horatio links the victim to Kyle's stepfather.