Wentworth Miller Wentworth Miller

Prison Break star Wentworth Miller will guest-star on House, TVLine reports.

The actor will play a patient of the week after House (Hugh Laurie) gets released from jail. "He plays a real altruist," creator David Shore tells the site. "And there's some question as to whether that's his symptom or not."

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The gig will mark Miller's first TV appearance in two years, when he appeared in a 2009 episode of Law & Order: Special Victims Unit.House returns Monday, Oct. 3 at 9/8c on Fox. Miller's episode will air later that month.