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Boston Legal
10:01 pm/ET ABC
Tonight's episode is on drugs. Now that doesn't mean this show's trademark frivolity is chemically induced. Rather, it's just that Denny's Alzheimer's prognosis gets a whole lot worse, and Alan appears before the Massachusetts Supreme Court to plead for his friend's access to an experimental medicine. In addition, Jerry and Katie help a girl whose acceptance to Harvard was rescinded after it's revealed she took nootropics, aka brain enhancers, for her SATs. — Joe Friedrich

For clips of Boston Legal, visit our Online Video Guide.

Shrek the Halls
8 pm/ET ABC
In this 2007 holiday special, the green guy is preparing to celebrate his expanded family's first Christmas, but that doesn't mean he's softening up. In fact, visits by Donkey, Puss in Boots, and Gingy soon spiral this celebration totally out of control, leaving Shrek none too merry. With the same voice cast from the movies (including Mike Myers, Cameron Diaz, Eddie Murphy and Antonio Banderas), the top-notch production has a good chance of being a Yuletide treat for many years to come.

For more Shrek, visit our Online Video Guide.

8 pm/ET NBC
Chuck's out of luck and pluck. Not only is his bizarro relationship with CIA ravisher Sarah still overly complicated, but Jill — his college sweetie and longtime love — turned out to be a spy. Chuck, still stung from that personal betrayal, keeps busy tonight, using spy work as a coping mechanism. Casey's also reeling (and we thought he lacked a heart) as he discovers his mentor (Carl Lumbly) has become a rogue agent. Meanwhile, Awesome's parents (Bruce Boxleitner, Morgan Fairchild) pay a visit. And we get more at Buy More: The efficiency expert (Tony Hale) works to reestablish the "employee of the month" contest. — Dean Maurer

For full episodes of Chuck, visit our Online Video Guide.

Gossip Girl
8 pm/ET CW
Romance is in the air at the annual Snowflake Ball...but on Gossip Girl, romance is always complicated. Since Chuck and Blair are currently just friends, they try to find the ideal date for one another — and because they're Chuck and Blair, they make a bet out of it. Meanwhile, Aaron's ex-girlfriend is interested in Dan, and this bothers Aaron's present girlfriend (aka Dan's ex-girlfriend), Serena. Then there's Jenny, Nate and Vanessa, three points of a potentially messy love triangle. — Jennifer Sankowski

For full episodes of Gossip Girl, visit our Online Video Guide.

Prison Break
9 pm/ET Fox
This series is sort of like the myth of Sisyphus: push that rock up to the top of the hill and... you know what happens next. So now it's Self who has Scylla, and the full extent of his treachery becomes clears in tonight's bloody episode. In fact, if  you can keep track of who's stabbing who in the back (and why), you just might be as smart as Michael. It also might be wise to keep in mind the No. 1 rule of diplomacy: Alliances shift but self-interest doesn't. — Paul Droesch

Catch up on Prison Break in our Online Video Guide.