The Oscar winner, 65, will play Joy, a cancer survivor who is using her unique experience to inspire others. "She's another cancer survivor who has used her cancer experience in a unique way trying to inspire other people," creator and executive producer Darlene Hunt tells the magazine. "She makes Cathy question whether she's doing enough with her own cancer experience."
Sarandon has guest-starred on Friends, ER and, most recently, 30 Rock. She has earned four Emmy nominations and will next co-star with Jason Segel and Ed Helms in Jeff Who Lives at Home, which comes out on March 16.
The Big C returns on April 8, 2012.