Witnesses reported hearing shots around 1:30 a.m. at the 10AK nightclub in West Hollywood, and Knight was subsequently taken by ambulance to a hospital and rushed into surgery, according to TMZ. He's expected to make a full recovery.
Two other people were also shot; their conditions are unknown.
The party's host, Brown — who infamously beat Rihanna the night before the 2009 Grammy Awards — took to Twitter to lament the fact that the awards show was marred by violence.
"It's disappointing that we as a society can't have fun or enjoy ourselves without any altercations sometimes," the born-again pacifist tweeted. "Miss me with the bulls---!!!"
Around midnight, rapper The Game arrived at the event and was denied entry after getting into a fight with security guards, though members of his entourage went inside, TMZ reports.
Incredibly, this isn't the first time Knight has been shot before the VMAs. In 2005, he was shot and robbed at Kanye West's pre-party in Miami.