Get ready for Round 2 of Rebel Wilson vs. the Kardashians!

The Pitch Perfect 2 actress tweeted on Wednesday that she would debate the reality stars "anywhere, anytime" about "any topic," and accused the family's publicist of running a "smear campaign" her.

Wilson says the supposed campaign began after she told an Australian radio show that she turned down the opportunity to present an MTV Video Music award with Kendall and Kylie Jenner. "What they stand for is totally against what I stand for," she said. "They seem a bit superficial and their careers aren't really based on talent."

Oprah defends the Kardashians and calls them hard workers

Afterwards Oprah Winfrey came out in support of the Kardashians, praising the work they put in on their reality show. "I went to film them as a family and I couldn't believe how hard they worked," she said. "We were there for seven hours, and they were gonna tape another seven hours after I left. No matter who you are, that is work."

Shortly after her initial tweet, Wilson had a change of heart and posted she was "over this little thing" and had sent the family flowers.

Video: The Talk hosts react to Rebel Wilson dissing Karashians and Jenners