The episode, which aired Sunday, grabbed headlines after Chris' date, a teenager Stewie calls "Down syndrome girl," tells him that her mother is the former governor of Alaska. Palin's 22-month-old son also has Down syndrome.
Palin labeled her Facebook note, posted late Monday, "Fox Hollywood: What a Disappointment," apparently differentiating the network from Fox News Channel, her newest employer. The 2008 Republican vice presidential candidate kept her comments on the episode brief but included a statement from her daughter, Bristol Palin.
"Are there any limits to what some people will do or say in regards to my little brother or others in the special-needs community?," the younger Palin wrote. "If the writers of a particularly pathetic cartoon show thought they were being clever in mocking my brother and my family yesterday, they failed. All they proved is that they're heartless jerks."
Family Guy creator/executive producer Seth MacFarlane responded to Sarah and Bristol Palin's remarks with a terse statement: "From its inception, Family Guy has used biting satire as the foundation of its humor. The show is an 'equal-opportunity offender.'"
Earlier this month, Palin used Facebook to chide White House chief of staff Rahm Emanuel for his use of the word "retarded."
Watch the clip below: