When Masters of Sex returns, it's 1966 and the Sexual Revolution is in full swing (so to speak).
Bill Masters' (Michael Sheen) wife Libby (Caitlin Fitzgerald) has not only accepted her husband's infidelity with his sexual research partner Virgina Johnson (Lizzy Caplan), but even views her as a friend. After all, who else understands her demanding husband so well? Their three-way marriage, however, is about to be tested when one of them gets knocked up.
The news comes as a surprise to everybody, including the man involved with the conception, and unfortunately, it couldn't have happened at a worse time: Bill and Virginia are on the brink of publishing their groundbreaking first book, Human Sexual Response, and any hint at loose morals could undermine their efforts.
What is a modern 1966 woman to do when faced with such a sticky situation? One thing you can definitely expect is an unusual solution to the problem, one that will have far-reaching consequences. After all, what is the Sexual Revolution good for if not to challenge traditional behavior and relationships?