Mark Harmon, Arsenio Hall Mark Harmon, Arsenio Hall

Mark Harmon has opened up about Cote de Pablo's shocking exit from NCIS.

During an appearance on The Arsenio Hall Show Thursday night, Harmon said Ziva's departure is no different from any of the other numerous "changes" the show has seen over its 11-season run. "It's up to this highly professional group to use that as a springboard to get better, to improve and to stay No. 1," Harmon said.

NCIS, Glee and more of this fall's biggest cast shakeups

Earlier this week, NCIS executive producer Gary Glasberg addressed de Pablo's decision in an open letter to fans, assuring viewers that, "Very often, extraordinary creativity comes out of adjustment. And so we find ourselves not dwelling on the past, but eager to guide you into the future of NCIS."

Watch Harmon discuss Ziva's exit, as well as a hilarious look at Arsenio and Harmon's past!

NCIS returns Tuesday, Sept. 24 at 8/7c on CBS.

(Full disclosure: is owned by CBS.)