L. Scott Caldwell L. Scott Caldwell

Lost alum L. Scott Caldwell will guest-star on Grey's Anatomy, a show rep tells TVGuide.com.

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Caldwell, who played Rose, a cancer patient who was healed by the island, on Lost, will play the wife of a patient participating in the Alzheimer's clinical trial that Derek is heading with Alex assisting.Her episode is scheduled to air Feb. 23, according to TVLine, which first reported the news.