DePaiva last appeared on the NBC daytime soap in February 2016 and was originally scheduled to reprise her role as Eve Donovan later that year, but she had to take a leave of absence while she battled leukemia.
But as she revealed in February, she's now cancer-free, and she's ready to make her Days return. She'll begin taping episodes soon for a late-October return.
DePaiva is best known for her 20-year stint as Blair Cramer on One Life to Live until that series' cancellation in 2013. She first appeared on Days in 2014.