"It is with great sadness that I have to report that my wife and best friend, Karen Black has just passed away, only a few minutes ago," Stephen Eckelberry wrote. "Thank you all for all your prayers and love, they meant so much to her as they did to me."
In 2010, Black was diagnosed with ampullary cancer, undergoing several treatments to battle the disease. By March, she was bed bound and down roughly 60 pounds. That same month, Black launched a GoFundMe.com page to raise $17,000 for a two-month treatment in Europe.
Black is survived by Eckelberry, her fourth husband, with whom she adopted a daughter, Claire. She was previously married to Charles Black, Robert Burton and K.M. Kit Carson, with whom she had a son, Hunter Carson.