Aniston, 41, is near a deal to guest-star in an early Season 2 episode, Entertainment Weekly reports. She follows in the footsteps of fellow Friends star Lisa Kudrow, who appeared as a volatile dermatologist in the middle of last season.
After starring together on Friends for 10 years, Aniston and Cox last shared the screen (and a lip-lock) on Cox's FX drama Dirt in 2007.
An ABC rep for the series refused to confirm the report.
Are you excited to see Aniston and Cox reunite? Which Friends star should stop by Cougar Town next?