We've seen our share of PSAs, but they usually don't tend to be as over-the-top ridiculous when trying to prove a point as this one. In this video, 30 Rock's Jack McBrayer stumbles across two lovely ladies who are completely and totally turned off by this juice box-drinking, Hootie and the Blowfish-listening loser. You'll have to wait until the end to understand how this hilarious skit has anything to do with the fight against cancer, but we have to give it to StandUp2Cancer.com for its fresh approach!