Calzona's Future, Mer's Motherhood and More Grey's Anatomy Scoop

Grey's Anatomykicks off its momentous 10th season right where we left off: during a super-storm that may have claimed the life of the Grey Sloan Memorial Hospital's most beloved doctor, Richard Webber (James Pickens Jr.). Will he survive the electrocution that left him seemingly lifeless in the closing moments the Season 9 finale?

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"No comment," spoilerphobe executive producer Shonda Rhimes says.

But don't worry, she was much less cagey about some of our favorite couples! How will Meredith (Ellen Pompeo) and Derek (Patrick Dempsey) handle parenthood? Can Callie (Sara Ramirez) and Arizona (Jessica Capshaw) make it? Is there hope for Cristina (Sandra Oh) and Owen (Kevin McKidd)? Get the scoop below:

Mer/Der family dynamic: Even though Meredith was already a mother to Zola, things will be very different now that she's given birth. "They have a newborn, which is very different from adopting a 1-year-old child," Rhimes says. "It's a very different idea to have a newborn who only sleeps two hours at a time, wakes up to be fed, and Meredith has to figure out how to breastfeed and all those other things. Also, having two children is very different from having one." As for whether that means she'll take a step back from the hospital, "We'll see her deal with what that choice means," Rhimes says. 

Arizona's infidelity: Callie and Arizona will have to face their issues head on, which treads on familiar territory for Callie, whom George (T.R. Knight) cheated on all those years ago. "It's not how she's handling it differently, but it's more, 'How does the fact that she's been cheated on before influence how she feels now? What is that going to mean for her?'" Rhimes ponders. "These characters have some very complex things to go through. I'm excited to see what this means for them."

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Cristina and Owen's future: The duo called it quits once again, realizing that they will never be on the same page when it comes to wanting to have children. "We're going to watch them grapple with what it means to have broken up at the end of the season and what that means for their future," Rhimes says. "For both of them, the hard part is that they love each other. They want very, very different things, but they love each other. If only she'd want to have babies, or if only he'd give up wanting kids, they'd be fine."

The big 200: "It's going to be special," Rhimes says of the season's fourth episode. "We're not going to go over-the-top big and do anything crazy because the beauty of doing a 200th episode is that we've done this 199 times. I want to see people in formal wear because that's always fun for me. I also want to see a little romance. But I also really want to deal with the fact that, to me, the biggest thing about the 200th is realizing and seeing that our original interns have grown up and they are these very badass surgeons at this point. They are no longer fumbling and confused. They are the ones giving the order. The 200th is going to be a big deal and we're very excited about it."

Dying for more Grey's Anatomy scoop? We'll be chatting with Rhimes again on Tuesday, so be sure to send your questions for her in the comments below!

Grey's Anatomy returns with a two-hour premiere on Thursday, Sept. 26 at 9/8c on ABC.