Uncle Joey Dave Coulier will be making a cameo in an episode of the new show as one of Sarah's (Paget Brewster) coworkers' patients, EWreports. His cameo follows Bob Saget's brief appearance in the show's pilot episode, (but before all three reunite on the upcoming Netflix revival series Fuller House).
Grandfathered stars Stamos as a bachelor whose life takes a sharp turn when he learns that he's both a father and a grandfather. Josh Peck stars as his long-lost son, and Brewster plays his mother.
VIDEO: John Stamos is sexy, smiling on the set of his new show