The actor appeared on The Late Show Thursday night and immediately tricked the host into handcuffing their wrists together.
"You're not going anywhere, David Letterman," Clooney said.
"Now, George. Is this something leftover from the bachelor days?" Letterman quipped back. Watch below.
Letterman's last Late Show airs Wednesday, May 20 at 11:30/10:30c. (Full disclosure: TVGuide.com is owned by CBS.)