The Marvel Cinematic Universe is about to blown wide open.

The first trailer forDoctor Strangepromises the weirdest, most mind-bending Marvel movie yet. Benedict Cumberbatch puts on his best Dr. House impression to star as Stephen Strange, an American doctor who becomes the Sorcerer Supreme after being trained by the Ancient One (Tilda Swinton).

Chiwetel Ejiofor, Mads Mikkelsen and Rachel McAdams also star in the trippy film, which is visually closer to Inception and The Matrix than any previous Marvel film.

Doctor Strange hits theaters on Nov. 4.