Cramsey died after suffering a brain aneurysm Tuesday morning, her agency, William Morris Endeavor, told the trade.
"At Denise's side were her fiancé Scott, best friend Risa and brother Billy. Continuing the spirit of charity and kindness that embodied Denise, her organs will be donated," WME said in a statement. "We thank everybody for their thoughts and prayers and words cannot express our sadness with the loss of Denise."
Cramsey worked for 69 News in Pennsylvania in the 1990s before serving as an executive producer on Trading Spaces, Extreme Makeover: Home Edition, and True Beauty. She most recently worked on the NBC reality series School Pride.
She was nominated for four Emmys, winning two for outstanding reality program for Extreme Makeover: Home Edition in 2005 and 2006.