Lee, 88, will guest-star in the seventh episode of the spy drama's fifth and final season. The site reports that Chuck (Zachary Levi) will meet Lee "in the most unexpected places." (Maybe Lee is also working for the CIA?)
"To say we're excited to have Stan Lee join us on the show is an understatement," series co-creator Chuck Fedak told the site. "His iconic characters and the epic worlds he imagined have been inspirations to all of us working on Chuck."
Lee, who is credited with co-creating dozens of Marvel's most famous comic book characters including The Hulk, Fantastic Four and X-Men, recently made a cameo appearance in Captain America: The First Avenger.
Chuck returns to action on Friday, Oct. 21 at 8/7c on NBC.