Drea de Matteo Drea de Matteo

Something tells us the Agents of S.H.I.E.L.D. do not want to be on her bad side.

The Sopranos alum Drea de Matteo is set to guest-star on an upcoming episode of the ABC series, TVGuide.com has learned.

The Emmy winner will play Karla Faye Gideon, a gifted woman who has an axe to grind against S.H.I.E.L.D. Karla teams up with Sky'e father, Cal (Kyle MacLachlan).

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The role marks a reunion for the de Matteo and MacLachlan, who co-starred together on Desperate Housewives. The actress most recently starred on Sons of Anarchy.

Marvel's Agents of S.H.I.E.L.D. returns with new episodes on Tuesday, March 3 at 9/8c on ABC.

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