Judd Apatow's comedy, starring Leslie Mann, Paul Rudd and Debbie and Pete are on the verge of turning 40. They have been married for several years and their daughters are growing up fast, but not everything is rosy. Both have problems with their businesses, and Pete's father is a constant drain on their resources. While they grapple with domestic issues, Pete and Debbie confront the reality of ageing, and what that means for their increasingly strained relationship.