Western crime drama is set in the American West in 1851 and revolves around brothers Eli and Charlie Sisters. The brothers are gunfighters hired by a wealthy businessman, known as the Commodore, to kill a man named Hermann Warm. The brothers pursue him across one thousand miles of 1850s Oregon desert to San Francisco, California. Eli is full of doubts about his career, while Charlie is enjoys whiskey and killing people. The journey of the two brothers is repeatedly interrupted by bloody encounters.