Irma Peterson was the typical dumb blonde secretary living with a roommate, Jane Stacy, in a run-down Manhattan apartment run by Mrs. O'Reilly. A neighbor was nutty Professor Kropotkin. Jane's boss and boyfriend was millionaire Richard Rhinelander III. During the second season, Jane Stacy moved to Panama and Kay Foster moved in with Irma; Irma's 7-year-old nephew Bobby also moved in. Irma also acquired a new boyfriend, Joe Vance, and a new neighbor, Mr. Corday, an actor.