Attorney and US Navy vet Stewart "Mac" McMillan is appointed Commissioner of Police for the city of San Francisco. He often handles the highest-profile cases personally. Helping him out on many of them is his wife Sally, whose father was a detective for the SFPD. In fact, Sally gets so involved that she often puts herself in harm's way. They are often assisted by Mac's loyal but somewhat inept assistant Sgt. Charlie Enright and their hard-drinking, smart-mouthed live-in maid Mildred. Sadly, a few years after Mac's appointment Sally dies in a plane crash. Also, Mildred quits her position and is replaced by her scatterbrained sister Agatha, and in later years Enright is promoted to lieutenant.
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