Home Sweetie Home is the story of Romeo (John Lloyd Cruz) and Julie (Toni Gonzaga), who live together with the latter's family under one roof. Julie's mother (Sandy Andolong) undoubtedly does not favor Romeo as her son-in-law because of his reputation as a ladies man, and prefers Jay-Jay (Jason Gainza) whom she considers fit for her daughter, seeing him as responsible. Still, the two decided to marry each other. However, in turn, Romeo has to deal with Julie's family in the best way he knows how.
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