"Empty Nest" is set in Miami and tells of the day to day misadventures of a widowed pediatrician named Harry Weston and his two adult daughters, Barbara and Carol, who have come back to live with him after failed marriages. Much of the humor is derived from Barbara and Carol's ongoing attempts, and failure to find the perfect partner, and leave the "nest" once again. There is also their skirt-chasing next door neighbor, Charlie Dietz, and Harry's southern nurse, Laverne Todd, who is unique for her unbelievable Hickory stories.
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