CIA is a crime drama centered on two unlikely partners - a fast-talking, rule-breaking loose cannon CIA case officer called Hart Hoxton (Tom Ellis), and a by-the-book, seasoned and smart FBI agent called Bill Goodman (Nick Gehlfuss) who believes in the rule of law. When this odd couple are assigned to work out of CIA's New York Station, they must learn to work together to investigate cases and criminals posing threats on U.S. soil, finding that their differences may actually be their strength.