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22 Episodes 1999 - 2000
Episode 1
Thu, Sep 23, 1999
The new team deal with incidents including a patient who dies following a routine liposuction procedure and a priest with a genital mutation.

Episode 2
Thu, Sep 30, 1999
Geiger and Waters argue over which patient is more deserving of a donor heart.
Episode 3
Thu, Oct 7, 1999
A newborn's life is in the hands of a heart surgeon who has Tourette's Syndrome.
Episode 4
Thu, Oct 14, 1999
Dr. McNeil puts the life of a young ballplayer in jeopardy while trying to save the boy's arm.
Episode 5
Thu, Oct 21, 1999
The surgeons of Chicago Hope work together in an attempt to save the life of Dr. Cacaci.
Episode 6
Thu, Oct 28, 1999
The widow of a heart attack victim wants to be impregnated with sperm from her husband's body but his parents object to the procedure. A young boy requires brain surgery to remove a tumour. Down in the basement, two medical transcribers plot to sell copies of a doctor's notes to a tabloid newspaper.
Episode 7
Thu, Nov 11, 199960 mins
A killer virus sweeps through the hospital, killing everyone who catches it.
Episode 8
Thu, Nov 25, 1999
Dr. Alberghetti performs experimental lung surgery with help, via satellite and the internet, from a doctor in Sri Lanka. Dr. Geiger helps his daughter Alicia prepare for her Thanksgiving play.
Episode 9
Thu, Dec 9, 1999
Jack & Aaron deal with shooting victims at a bookie joint in an old warehouse while the shooter keeps the police at bay. Drs. Alberghetti and Hanlon fight to save a woman who was brutally stabbed.
Episode 10
Thu, Jan 6, 2000
A woman refuses treatment because of religious beliefs; Dr. Hanlon fights to provide free treatment; multiple piercings cause a young man's staph infection and heart problems; the hospital's Web site stirs angst among the staff members.
Episode 11
Thu, Jan 13, 2000
Dr. Simon performs brain surgery on a friend suffering from Parkinson's and then has to deal with the man's mother when things go wrong. Dr. Geiger deals with a doctor who is doing research into human cloning and with an elderly patient who is ready to die.
Episode 12
Thu, Jan 20, 2000
Keith's estranged aunt, Dr. Odelia Wilkes, is brought in to perform surgery on a tuberculosis patient. Dr. Simon struggles to diagnose a patient whose twin sister died from leukaemia.
Episode 13
Thu, Feb 3, 2000
Jack and Jeremy help a teenage girl who was born a boy. Gina and Francesca treat an elderly woman suffering from Alzheimer's.
Episode 14
Thu, Feb 10, 2000
A father must choose which of his two dying children will get his liver donation. Dr. Rose Weber suffers a seizure at work. Aaron and Gina deal with their budding relationship.
Episode 15
Thu, Feb 17, 2000
At the same time his daughter Alicia needs heart surgery, Geiger is pressured by the board to make massive cuts to the hospital's budget. Conjoined twins arrive in the emergency room, one suffering a cut on his leg, the other needing an appendectomy.
Episode 16
Thu, Feb 24, 2000
Gina helps a mentally challenged couple after discovering a surgeon at the hospital had sterilized the woman years earlier.
Episode 17
Thu, Mar 30, 2000
A steroid using wrestler with a knee injury learns she may have cancer. Aaron and Gina come up with a plan to use hypothermia on a young girl to better her chances of surviving brain surgery. Keith's son Ray asks his dad for help with a sick tarantula.
Episode 18
Thu, Apr 6, 200060 mins
An old friend of Jack's shows up in the ER with a minor gunshot wound and a major heart defect. The conjoined twins return to the hospital and when Jeremy discovers one of them has developed pancreatic cancer, she tries to convince them to have separation surgery.
Episode 19
Thu, Apr 13, 200060 mins
Chicago Hope is bought by an HMO and new CEO Hugh Miller starts making cuts. A young couple learns their pregnancy is not progressing normally.
Episode 20
Thu, Apr 20, 200060 mins
Gina and Aaron are given permission to perform experimental brain surgery on a paralyzed patient but Jack has to jump through hoops to be allowed to do a hip replacement on an ex-football player. Jeremy and Francesca discuss their feelings about new CEO Hugh Miller.
Episode 21
Thu, Apr 27, 200060 mins
After suffering a medical emergency, Hugh experiences care at Chicago Hope firsthand. A woman who went into a coma giving birth reawakens after 15 years and is reunited with her husband and daughter. A man is being denied coverage for life saving heart surgery by his HMO who consider the procedure to be experimental.

Episode 22
Thu, May 4, 200060 mins
A patient with a spinal cord injury asks the surgeons to implant a microchip he created that he believes will help him move. Stanwood Consolidated accepts a purchase offer from Hoyt Hospital Services who plan to close the hospital but Hugh makes a last ditch gamble to save Chicago Hope. Gina suffers an ectopic pregnancy.