The ultimate disaster movie parody: A nuclear-powered bus is going non-stop from New York City, New York to Denver, Colorado, and is plagued by disasters because of the machinations of a mysterious group allied with the oil lobby. When the driver is injured, a washed-up, down-on-his-luck-but-used-to-be-great type who used to be engaged to the inventor's daughter is brought in to drive the giant bus, which includes a one-lane swimming pool and a one-lane bowling alley.