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George and Joan are going out for the night. George tells Spike to keep an eye on the house while they are away. Butch the cat, who is also owned by George and Joan, telephones his friends Lightning, Topsy, and Meathead (who is for some reason portrayed as a gray cat instead of a brown cat with a red toupee) to come to a party at his house. And hi-jinx ensue.
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