Picking up mere moments after the events of the 2010 film, Megamind’s former villain team, The Doom Syndicate, returns to Metro City with a nefarious plan to launch the entire city to the Moon, as evil syndicates are prone to do. To thwart the plan, Megamind must keep up his evil pretenses while assembling his own heroic team of Roxanne, Ol’ Chum, and Keiko to save the day.