In the early years of the AIDS epidemic, the disease was considered a death sentence affecting communities, like the LGBT ones, whom many in power felt deserved it. This film tells the story of how militant activists like ACT-UP and TAG pushed for a meaningful response to this serious public-health problem. As the activists struggled against political indifference, religious hostility, corporate greed, and apparently-skewed scientific research priorities with determination and sheer audacity, they produced a political wave that would lead to an effective treatment regime and advance LGBT rights beyond anyone's expectations.