Tripod, sometime director of a dermatological clinic called the House of Skin, is searching for his mentor, the mad dermatologist Antoine Rouge. Rouge has disappeared following a catastrophic plague resulting from cosmetic products, which has killed the entire population of sexually mature women. Tripod joins a succession of organisations and meets various men trying to adjust to a defeminised world. Sensing the presence of Antoine Rouge, Tripod comes upon a strange group.
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